How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?
Identifieur interne : 002272 ( Main/Exploration ); précédent : 002271; suivant : 002273How cautious should we be when assessing apathy with the Unified Parkinson's Disease Rating Scale?
Auteurs : Lindsey Kirsch-Darrow [États-Unis] ; Laura B. Zahodne [États-Unis] ; Chris Hass [États-Unis] ; Ania Mikos [États-Unis] ; Michael S. Okun [États-Unis] ; Hubert H. Fernandez [États-Unis] ; Dawn Bowers [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Mood Disorders (diagnosis), Mood Disorders (etiology), Parkinson Disease (complications), Parkinson Disease (psychology), Parkinson's disease, Psychiatric Status Rating Scales, ROC Curve, Sensitivity and Specificity, UPDRS, apathy, assessment, mood disorders.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Mood Disorders.
- etiology : Mood Disorders.
- psychology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, ROC Curve, Sensitivity and Specificity.
Abstract
Current practice often assesses apathy with a single item from the Unified Parkinson's Disease Rating Scale (UPDRS, item 4). Yet, the relationship between the UPDRS item 4 and the validated Apathy Scale (AS) is unknown. The purpose of this study was to evaluate the operating characteristics of UPDRS item 4 in relation to the AS. Three hundred and one patients with PD were administered the AS and the UPDRS. We compared the UPDRS item 4 to the standard AS classification of ≥14 as apathetic. A receiver operating characteristics (ROC) curve was obtained, and sensitivity, specificity, positive, and negative predictive power were calculated. The ROC curve showed area under the curve as 0.75. A cut‐off of 1 had good sensitivity (81%) but poor specificity (53%; high false positive rate). A cut‐off point of 2 had acceptable specificity (87%) but poor sensitivity (52%, high false negative rate). Continuing to increasing the cut‐off point (e.g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS. © 2009 Movement Disorder Society
Url:
- https://api.istex.fr/document/A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045863
DOI: 10.1002/mds.22437
Affiliations:
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Le document en format XML
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Zahodne</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Hass, Chris" sort="Hass, Chris" uniqKey="Hass C" first="Chris" last="Hass">Chris Hass</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mikos, Ania" sort="Mikos, Ania" uniqKey="Mikos A" first="Ania" last="Mikos">Ania Mikos</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-15">2009-04-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="684">684</biblScope><biblScope unit="page" to="688">688</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A9EFFFAC3A8B1ACC2342111104B9B49338DE07A9</idno><idno type="DOI">10.1002/mds.22437</idno><idno type="ArticleID">MDS22437</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mood Disorders (diagnosis)</term><term>Mood Disorders (etiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Parkinson's disease</term><term>Psychiatric Status Rating Scales</term><term>ROC Curve</term><term>Sensitivity and Specificity</term><term>UPDRS</term><term>apathy</term><term>assessment</term><term>mood disorders</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Psychiatric Status Rating Scales</term><term>ROC Curve</term><term>Sensitivity and Specificity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Current practice often assesses apathy with a single item from the Unified Parkinson's Disease Rating Scale (UPDRS, item 4). Yet, the relationship between the UPDRS item 4 and the validated Apathy Scale (AS) is unknown. The purpose of this study was to evaluate the operating characteristics of UPDRS item 4 in relation to the AS. Three hundred and one patients with PD were administered the AS and the UPDRS. We compared the UPDRS item 4 to the standard AS classification of ≥14 as apathetic. A receiver operating characteristics (ROC) curve was obtained, and sensitivity, specificity, positive, and negative predictive power were calculated. The ROC curve showed area under the curve as 0.75. A cut‐off of 1 had good sensitivity (81%) but poor specificity (53%; high false positive rate). A cut‐off point of 2 had acceptable specificity (87%) but poor sensitivity (52%, high false negative rate). Continuing to increasing the cut‐off point (e.g., 3, 4) continues to increase specificity at the expense of dramatically reducing sensitivity. These findings suggest the use of caution when screening for apathy with item 4 due to its poor sensitivity in relation to the AS. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Kirsch Arrow, Lindsey" sort="Kirsch Arrow, Lindsey" uniqKey="Kirsch Arrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name></region><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><name sortKey="Hass, Chris" sort="Hass, Chris" uniqKey="Hass C" first="Chris" last="Hass">Chris Hass</name><name sortKey="Mikos, Ania" sort="Mikos, Ania" uniqKey="Mikos A" first="Ania" last="Mikos">Ania Mikos</name><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S." last="Okun">Michael S. Okun</name><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B." last="Zahodne">Laura B. Zahodne</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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